Results:

In total, 813 adult patients were hospitalized with COVID-19 during the study period. After exclusion of 613 patients who remained hospitalized or not confirmed to have COVID-19 infection by RNA testing, and excluding nine patients with incomplete medical records, 191 patients were included in the final analysis. Of this population, 54 patients died and 137 were discharged from the hospital. The median age was 56.0 years (interquartile range [IQR], 46.0-67.0 years), and ranged from 18 to 87 years. Comorbidities were present in approximately 50% of patients, with hypertension (30%) being the most common, followed by diabetes (19%) and coronary artery disease (8%).

The most common symptoms on admission were fever (94%) and cough (79%). The majority (95%) of patients received antibiotics and 21% received antivirals (lopinavir/ritonavir). The median time from illness onset to discharge was 22.0 days (IQR, 18.0-25.0 days) and the median time to death was 18.5 days (IQR, 15.0-22.0 days). Mechanical ventilation was required in 32 patients (17%), of whom 31 (97%) died. Extracorporeal membrane oxygenation was used in three patients, all of whom died. Common complications included sepsis (59%), acute respiratory distress syndrome (31%), heart failure (23%), and septic shock (20%), coagulopathy (19%), and acute cardiac injury (17%).

For multivariable logistic regression analysis, 171 patients with complete data were included (53 nonsurvivors and 118 survivors). Increased odds of in-hospital death were associated with older age (odds ratio [OR], 1.10; 95% confidence interval [CI], 1.03-1.17), higher Sequential Organ Failure Assessment (SOFA) score (OR, 5.65; 95% CI, 2.61-12.23), and d-Dimer >1 µg/ml (OR, 18.42; 95% CI, 2.64-128.55) at admission. For survivors, the mean duration of viral shedding was 20.0 days (IQR, 17.0-24.0 days) from illness onset.