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Treatment Optimization for Blood Pressure With Single-Pill Combinations in India - TOPSPIN
Contribution To Literature:
The TOPSPIN trial showed that three different antihypertensive regimens result in similar control of blood pressure.
Description:
The goal of the trial was to evaluate three antihypertensive regimens among patients with hypertension.
Study Design
- Randomized
- Parallel
Patients with hypertension were randomized to starting doses of amlodipine plus perindopril vs. amlodipine plus indapamide vs. perindopril plus indapamide. Doses were increased at 2 months, unless systolic blood pressure was <120 mm Hg.
- Total number of enrollees: 1,981
- Duration of follow-up: 6 months
- Median patient age: 52 years
- Percentage female: 42%
- Percentage with diabetes: 19%
Inclusion criteria:
- Indians 30-79 years of age
- Office systolic blood pressure 140-159 mm Hg on one antihypertensive agent, or
- Office systolic blood pressure 150-179 mm Hg on no treatment
Exclusion criteria:
- Patients with established cardiovascular disease, cerebrovascular disease, and renal impairment
Principal Findings:
The primary outcome, change in ambulatory systolic blood pressure from baseline to 6 months, was: -14.5 mm Hg in the amlodipine plus perindopril group vs. -13.3 mm Hg in the amlodipine plus indapamide group vs. -13.9 mm Hg in the perindopril plus indapamide group.
Interpretation:
Among patients with hypertension, three different antihypertensive regimens (amlodipine plus perindopril vs. amlodipine plus indapamide vs. perindopril plus indapamide) result in similar control of blood pressure.
References:
Presented by Dr. Dorairaj Prabhakaran at the American Heart Association Scientific Sessions, Chicago, IL, November 17, 2024.
Clinical Topics: Prevention, Hypertension
Keywords: Antihypertensive Agents, Blood Pressure, Hypertension, AHA24, AHA Annual Scientific Sessions
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