The cover story of the latest issue of CardioSource WorldNews: Interventions examines the challenges of peripheral artery disease (PAD) and critical limb ischemia (CLI). This month’s Peripheral Matters discusses the updated ACC/AHA guidelines for lower-extremity PAD, while the NCDR Update reports on two studies presented at the 2016 Transcatheter Cardiovascular Therapeutics (TCT) meeting that used data from the STS/ACC TVT Registry. The issue’s ACCEL column asks if the debate between bivalirudin and heparin is over. See the full issue at ACC.org/CSWNI.