Cardiovascular imaging is growing rapidly in terms of new technology and novel avenues of investigation, but high-quality evidence for its utility – especially in positively influencing clinical outcomes – is lacking. To further define the optimal role of cardiac imaging in managing various cardiovascular diseases around the world, JACC: Cardiovascular Imaging is planning a themed issue showcasing quality evidence that defines or clarifies the clinical utility of cardiovascular imaging. Original research manuscripts including randomized controlled trials (RCTs), sub-analysis of RCTs, meta-analysis, systematic reviews, simulation and/or "in silico" studies, and methodology papers that describe planned RCTs will be considered. Submissions are due by June 30. Review submission instructions here.