His bundle pacing may have significant potential for future applications in patients who are traditional candidates for right ventricular pacing, as well as cardiac resynchronization therapy, according to a council perspective from ACC's Electrophysiology Section Leadership Council published Aug. 13 in the Journal of the American College of Cardiology.

Pugazhendhi Vijayaraman, MD, FACC, et al., provide a comprehensive review of the anatomy of His bundle, early clinical observations and current approaches to permanent His bundle pacing.

"This technique holds potential and requires further validation in larger studies with longer follow-up," the authors write. "It is also clear that collective and collaborative efforts from physician scientists, industry partners, scientific societies and regulatory authorities will be required to successfully develop this technology and advance our understanding of the physiology of pacing."

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