The latest issue of JACC: CardioOncology includes research dedicated to the growing knowledge surrounding physical activity and lifestyle interventions in cancer and cardiovascular disease. Don't miss state-of-the-art reviews on cardiometabolic comorbidities in cancer survivors, and cardiovascular disease in myeloproliferative neoplasms. Other topics include targeted therapies, the prevalence of cardiovascular disease in patients with potentially curable malignancies, polygenic risk scores and more. In addition, a perspective from Ukraine outlines the tragic impact of the war on cardio-oncology care, and the "How To" manuscript offers practical advice on treating renal cell carcinoma. Finally, the Editor's Page details Bonnie Ky, MD, FACC's hope for cardio-oncology and her gratitude to the editorial board for their contributions. Read the latest issue and don't forget to subscribe to email alerts to receive the eTables of Contents for future issues.