The first issue of JACC: Case Reports – the newest JACC Journal – is now live. The first of its kind for the family of journals, JACC: Case Reports promotes clinical cases and clinical problem solving in an online, open access format. The first issue outlines the vision for the journal from Editor-in-Chief Julia Grapsa, MD, PhD, FACC, and features a wide variety of cases ranging from multiple interventional procedures as an alternative to cardiac transplantation to an unusual cause of bidirectional ventricular rhythm. Other features include imaging vignettes; a global health report on building a strong network of female cardiovascular clinician scientists in Africa; a closer look at mental health considerations among clinicians; and a perspective on art and medicine. Read the issue at JACC.org/CaseReports.