Functional Testing Underlying Revascularization - FUTURE

Aug 25, 2018
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Author/Summarized by Author:
Anthony A. Bavry, MD,MPH,FACC
Summary Reviewer:
Deepak L. Bhatt, MD, MPH, MBA, FACC
Trial Sponsor:
French Health Ministry
Date Presented:
08/25/2018
Date Updated:
08/25/2018
Original Posted Date:
08/24/2018
References

Contribution To Literature:

The FUTURE trial was terminated early, but showed similar event rates for FFR-guided versus angiography-guided revascularization.

Description:

The goal of the trial was to evaluate fractional flow reserve (FFR)-guided revascularization compared with angiography-guided revascularization among patients with ≥2 coronary stenoses (≥50%).

Study Design

  • Randomized
  • Parallel

Patients with multivessel coronary artery disease were randomized to FFR-guided revascularization versus angiography-guided revascularization.

Inclusion criteria:

  • Stable patients with at least 2 coronary stenoses (≥50%).
  • Total number of enrollees: 864
  • Duration of follow-up: 1 year
  • Percentage with diabetes: 32%

Other salient features/characteristics:

  • SYNTAX score: mean 18.5

Principal Findings:

The primary outcome, all-cause death, myocardial infarction, or stroke, occurred in 14.4% of the FFR group compared with 14.6% of the angiography group (p = 0.94).

Adverse events were higher in the FFR group when SYNTAX score was ≥32.

Interpretation:

Among patients with multivessel coronary disease, FFR-guided revascularization resulted in similar outcomes compared with angiography-guided revascularization. Unfortunately, this trial was terminated early due to an unexplained increase in mortality in the FFR group.

References:

Presented by Dr. Gilles Rioufo at the European Society of Cardiology Congress, Munich, Germany, August 25, 2018.

Keywords: ESC Congress, ESC18, Angina Pectoris, Coronary Artery Disease, Coronary Stenosis, Fractional Flow Reserve, Myocardial, Myocardial Infarction, Myocardial Ischemia, Myocardial Revascularization, Stroke


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