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Amy Murphy amurphy@acc.org,
(202) 375-6476
October
2, 2009
American College of Cardiology and Society of Thoracic Surgeons
Awarded NIH Comparative Effectiveness Grant to Study Angioplasty
and Surgery
ACC and STS to study comparative effectiveness
of PCI and CABG
The National Heart, Lung, and Blood Institute of the National
Institutes of Health (NIH) has awarded a grant to the American
College of Cardiology (ACC) in partnership with The Society
of Thoracic Surgeons (STS) to study the comparative effectiveness
of the two forms of coronary revascularization; percutaneous
coronary intervention (PCI) and coronary artery bypass graft
(CABG) surgery. This study will compare catheter-based and
surgery-based procedures using existing databases from the
ACC and STS, as well as the Centers for Medicare and Medicaid
Services’ MEDPAR data. By linking these three databases,
the study will help physicians make better decisions and improve
healthcare for patients with coronary artery disease.
Dr. William Weintraub, principal investigator on the study
and chair of the ACC’s National Cardiovascular Data
Registry (NCDR) CathPCI Registry Steering Committee said,
“There remains considerable uncertainty about the best
strategy between catheter-based and surgery-based approaches in
patients requiring revascularization for coronary artery disease.
This collaboration between the ACC and STS will allow us to
address this vital question. By having available to
us combined databases of over 10 million people, we will also
be able to address concerns about choice in critical subgroups
such as patients with other severe diseases and the elderly.
This grant will offer a model for how to pursue comparative
effectiveness research using large clinical databases."
The study will set a standard for combining clinical databases
with administrative databases to study comparative effectiveness
of therapies in large patient populations as well as help
to inform shared decision making between physicians and patients
about the best approach for their treatment. The approach
used in this project can be adopted by other specialties and
their professional societies for comparative effectiveness
studies and quality improvement initiatives, and the techniques
of analysis should have broad application to the entire field
of medicine.
“This has potential to be a significant study, given
the focus of the research (PCI vs. CABG), use of the two most
prominent clinical registries in the country, and the fact
that collaboration between STS and ACC covers the entire spectrum
of adult cardiovascular disease. To my knowledge there
is no other research that has approached the scope of this
project,” said Dr. Fred H. Edwards, also principal investigator
on the study and chair of the STS Workforce on National Databases.
This is a joint project of the ACC and STS. Duke Clinical
Research Institute (DCRI) will perform the analysis for clinical
outcomes and Christiana Care Center for Outcomes Research
(CCOR) will perform the analysis for economic outcomes.
In addition, PERFUSE Angiographic Core Laboratories and
Data Coordination Center will be performing detailed angiographic
analysis on 2,000 angiograms of patients undergoing PCI in
order to determine their SYNTAX score. Led by Drs. Weintraub
and Edwards, a steering committee of investigators representing
ACC, STS, DCRI, CCOR and PERFUSE will be responsible for the
administration and conduct of this study. This award has been
issued under the American Recovery and Reinvestment Act of
2009 and is in the amount of $4,026,764 over the two year
period of the study.
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Disclaimer:
The project described above is supported by Award Number
RC2HL101489 from the National Heart, Lung, And Blood Institute.
The content is solely the responsibility of the authors and
does not necessarily represent the official views of the National
Heart, Lung, And Blood Institute or the National Institutes
of Health.
About the ACC:
The American College of Cardiology is leading the way to optimal
cardiovascular care and disease prevention. The College is
a 37,000-member nonprofit medical society and bestows the
credential Fellow of the American College of Cardiology upon
physicians who meet its stringent qualifications. The College
is a leader in the formulation of health policy, standards
and guidelines, and is a staunch supporter of cardiovascular
research. The ACC provides professional education and operates
national registries for the measurement and improvement of
quality care. More information about the association is available
online at www.acc.org .
About STS:
The Society of Thoracic Surgeons is a not-for-profit
organization representing more than 5,800 surgeons, researchers
and allied health professionals worldwide who are dedicated
to ensuring the best possible outcomes for heart, lung, esophageal
and other surgical procedures of the chest. Founded in 1964,
the mission of STS is to enhance the ability of cardiothoracic
surgeons to provide the highest quality patient care through
education, research and advocacy. For more information about
STS, please visit www.sts.org.
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